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Targeted Nanomedicine for Breast Cancer Therapy

by Shivani Rai Paliwal
Publisher: Academic Press
Release Date: 2022-07-15
Genre: Business & Economics
Pages: 176 pages
ISBN 13: 0877882487
ISBN 10: 9780877882480
Format: PDF, ePUB, MOBI, Audiobooks, Kindle

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Synopsis : Targeted Nanomedicine for Breast Cancer Therapy written by Shivani Rai Paliwal, published by Academic Press which was released on 2022-07-15. Download Targeted Nanomedicine for Breast Cancer Therapy Books now! Available in PDF, EPUB, Mobi Format. Worldwide, breast cancer is the most common cancer in women, however, breast cancer therapy is always challenging. This book aims to help researchers remain updated on the most targeted nanomedicine research available. -- Targeted Nanomedicine for Breast Cancer Therapy provides a compilation of treatment approaches for breast cancer, including conventional receptor targeting methods and novel strategies like stimuli responsive methods and tumor micro-environment responsive strategies. This book compiles the most important information on the state-of-the-art therapeutics, including breast cancer biomarkers and design principles of bio-responsive nanosystems. Presented in two parts, sections cover basic and receptor mediated targeting approaches and examine tumor microenvironment mediated approaches. This is a useful book for pharmaceutical scientists and basic and clinical scientists working in the research area of breast cancer and drug discovery both from academics and industry. Worldwide, breast cancer is the most common cancer in women, however, breast cancer therapy is always challenging. This book aims to help researchers remain updated on the most targeted nanomedicine research available. Highlights promising breast cancer targets to help design nanomedicines and stimuli-triggered methods for cancer imaging and treatments Provides in-depth exploration of targeted breast cancer therapy, along with highlights to quickly understand the most important points Explores cutting-edge research in the area of targeted nanomedicine and drug delivery, including nanotheranostics for breast cancer therapy

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Targeted Nanomedicine for Breast Cancer Therapy
Language: en
Pages: 590
Authors: Shivani Rai Paliwal, Rishi Paliwal
Categories: Business & Economics
Type: BOOK - Published: 2022-07-15 - Publisher: Academic Press

Targeted Nanomedicine for Breast Cancer Therapy provides a compilation of treatment approaches for breast cancer, including conventional receptor targeting methods and novel strategies like stimuli responsive methods and tumor micro-environment responsive strategies. This book compiles the most important information on the state-of-the-art therapeutics, including breast cancer biomarkers and design principles of bio-responsive nanosystems. Presented in two parts, sections cover basic and receptor mediated targeting approaches and examine tumor microenvironment mediated approaches. This is a useful book for pharmaceutical scientists and basic and clinical scientists working in the research area of breast cancer and drug discovery both from academics and industry. Worldwide, breast cancer is the most common cancer in women, however, breast cancer therapy is always challenging. This book aims to help researchers remain updated on the most targeted nanomedicine research available. Highlights promising breast cancer targets to help design nanomedicines and stimuli-triggered methods for cancer imaging and treatments Provides in-depth exploration of targeted breast cancer therapy, along with highlights to quickly understand the most important points Explores cutting-edge research in the area of targeted nanomedicine and drug delivery, including nanotheranostics for breast cancer therapy
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Pages: 360
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The book covers the latest developments in biologically-inspired and derived nanomedicine for cancer therapy. The purpose of the book is to illustrate the significance of naturally-mimicking systems for enhancing the dose delivered to the tumor, to improve stability, and prolong the circulation time. Moreover, readers are presented with advanced materials such as adjuvants for immunostimulation in cancer vaccines. The book also provides a comprehensive overview of the current status of academic research. This is an ideal book for students, researchers, and professors working in nanotechnology, cancer, targeted drug delivery, controlled drug release, materials science, and biomaterials as well as companies developing cancer immunotherapy.
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Pages: 438
Authors: Nanasaheb D. Thorat, Joanna Bauer
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Language: en
Pages: 149
Authors: Radhika Narayanaswamy
Categories: Cancer
Type: BOOK - Published: 2020 - Publisher:

"Cancer therapy in the recent years has evolved with the development of novel targeted drug delivery systems. The conventional chemotherapy approach is plagued by side effects and numerous disadvantages such as low bioavailability, poor solubility of drugs, toxicity, non-specific drug action and so forth. With the main goal of producing a drug delivery vehicle that is optimally designed to address the many limitations associated with the conventional chemotherapy, the work has been designed as follows: Different lipid-based targeted formulations were prepared, such as the tumor-targeting micelles and liposomes, and the in vitro effects of the formulations on pancreatic and breast cancer cells have been studied to determine their optimal therapeutic effects and their ability to minimize adverse off-target effects. Keeping in mind the need for an ideal therapy requirement for life threatening illnesses, hard to treat pancreatic cancer and the very commonly diagnosed cancer among women, breast cancer, were chosen as the targets for testing designed nano-preparations. The first approach was to develop polymeric micelles self-assembled with a single drug, paclitaxel and a targeting agent, a peptide sequence derived from phage coat protein. The drug is hydrophobic and poorly soluble in aqueous solvents that limit its pharmaceutical applications despite high efficacy. Cell viability studies on PANC-1 pancreatic cancer cells using the targeted phage micelle preparation produced significantly higher cell death of ~45 % while the non-targeted preparation caused only about ~30% cell death at 750ng/ml concentration of paclitaxel. Significantly higher cell death was observed at 1.5 and 2.75 mg/ml concentrations of paclitaxel-loaded in the formulation, that was dose and time dependent. More than a 30% increase in caspase3/7 activity was observed in vitro in a monolayer of PANC-1 cells while the in vivo data on lactate dehydrogenase release indicated a significantly enhanced apoptosis in the PANC-1 spheroid model upon treatment with the targeted micelle preparation. The second approach utilized liposomes modified with monoclonal antibody 2C5 (mAb 2C5) as targeting ligand for breast cancer therapy. The study is important in that a combination of 2 drugs, paclitaxel, a microtubule inhibitor, and salinomycin, an anti-cancer stem cell targeting agent, has been used. The main goal with the use of combination chemotherapeutics was to eliminate not just the bulk cancer cells as with conventional chemotherapy, but also the cancer stem cells, or the tumor-initiating cells, in the core of the tumor to eliminate possibilities of cancer metastasis and recurrence. The study produced promising results for cellular interaction, uptake and cytotoxicity in vitro as was observed both quantitively and qualitatively. Interaction of the mAb 2C5-targeted liposomes was greater than ~3.25-fold with SK-BR-3 breast cancer cells, while the same formulation showed over a ~1.3-fold increase in interaction with the MDA-MB-231 breast cancer cells in comparison to the other controls used. A significantly enhanced fluorescence signal upon treatment of both the breast cancer cells with rhodamine-labeled mAb 2C5-targeted liposomes was observed in comparison to the unmodified liposomes that supported cellular specificity and enhanced cellular uptake of the antibody-targeted formulation. The average of the corrected total cell fluorescence (CTCF) plotted for the mAb 2C5-modified liposome-treated cells from three different locations on the fluorescence image was statistically significant (p £ 0.05) in comparison to that of the unmodified liposome-treated cells in both the cell lines. There was a ~4.5-fold and a ~3.0-fold increase in average CTCF with the mAb 2C5-modified liposomes in comparison to the unmodified liposomes in SK-BR-3 and MDA-MB-231 cells respectively. The quantitative data was a further confirmation for the enhanced cellular uptake of the formulations in both the cell lines. Holographic monitoring confirmed improved cellular killing by showing visible differences in cellular morphology, cell division and proliferation over time (48 hours) that validated the efficacy of the mAb-targeted liposomal formulation in MDA-MB-231 cancer cells. 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